Organic solvent tolerance and fluoroquinolone resistance in Klebsiella pneumoniae clinical isolates
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چکیده
منابع مشابه
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
The MICs of ciprofloxacin for 33 clinical isolates of K. pneumoniae resistant to extended-spectrum cephalosporins from three hospitals in Singapore ranged from 0.25 to >128 microg/ml. Nineteen of the isolates were fluoroquinolone resistant according to the NCCLS guidelines. Strains for which the ciprofloxacin MIC was >or=0.5 microg/ml harbored a mutation in DNA gyrase A (Ser83-->Tyr, Leu, or II...
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ABSTRACT Background and Objectives: The resistance of gram-negative bacteria to antibiotics has become a serious problem, which imposes a significant increase in treatment costs. Klebsiella pneumoniae is an important nosocomial pathogen from the Enterobacteriaceae family. The aim of this study was to investigate the frequency and pattern of antibiotic resistance in K. pneumoniae strains isolat...
متن کاملMechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.
Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolat...
متن کاملEvaluation of Resistance to Fluoroquinolones and Its Relationship whit parC Gene Mutation in Klebsiella pneumoniae Clinical Isolates
Background & Objective: Klebsiella pneumoniae has received attention due to a wide range of diseases and antibiotic resistance.The resistance to fluoroquinolones in gram-negative bacteria is often due to chromosomal mutations in the gyr and par genes. This research aimed at investigating the pattern of fluoroquinolone resistance and its relation with a mutation in the parC gene among clinical i...
متن کاملInvestigating the Resistance of Klebsiella Pneumoniae Clinical Isolates Producing Carbapenemase and ESBL Enzymes to Colistin and Fosfomycin Antibiotics
Introduction: A Klebsiella pneumoniae bacterium, which is the most important species of the Klebsiella genus, mainly causes hospital infections. Moreover, it has a high resistance to most of the available antibiotics, which has caused concern among doctors all over the world. Therefore, the amount of antibiotic resistance and the effect of these antibiotics on Klebsiella pneumoniae isolates pr...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2009
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkp295